NNRT-IN-2

CAT: 0804-HY-163110Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-163110Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC50 of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics[1].
CAS Number
[2999794-78-2]
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nnrt-in-2.html
Solubility
10 mM in DMSO
Smiles
CN1C(NN=C1CN2C=CC(C(F)(F)F)=C(C2=O)OC3=C4C=CN=CC4=CC=C3)=O
Molecular Formula
C19H14F3N5O3
Molecular Weight
417.34
References & Citations
[1]Zhao LM, et al. Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility. Acta Pharm Sin B. 2023 Dec;13 (12) :4906-4917.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-175519NNRT-IN-11
HY-162720NNRT-IN-4
HY-149928NNRT-IN-1
HY-178923NNRT-IN-14
HY-174417NNRT-IN-10
HY-174303NNRT-IN-9
HY-172408NNRT-IN-6
HY-169207NNRT-IN-5
HY-149338NNRT-IN-3
HY-178341NNRT-IN-13

Alternative Products

CatalogName
T87027-01NNRT-IN-2
T211185-01NNRT-IN-8
T211267-01NNRT-IN-9
T201040-01NNRT-IN-5
T210051-01NNRT-IN-4
T212521-01NNRT-IN-11
T210761-01NNRT-IN-10
T205661-01NNRT-IN-6
PC1003049-012,2,2-Trifluoroethyl 2,2,2-trichloroacetate
H 038-0052'- , 2''-, 2''', 2'''', 2''''', 2''''''- Hexadeoxy- 2'-, 2'', 2''', 2'''', 2''''', 2''''''- hexafluoro- cyclic hexaadenosine monophosphate (2',2'',2''',2'''',2''''',2''''''-Hexa-F-c-hexadAMP / cFA6), sodium salt

Popular Products