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NNRT-IN-10

CAT: 804-HY-174417Size: 1 EachDry Ice: NoHazardous: No
1 EachSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NNRT-IN-10 is a potent, selective and orally active non-nucleoside HIV-1 reverse transcriptase (NNRTI) inhibitor with with an EC50 values ranging from 1.16 to 18.3 nM for HIV and its mutant strains. NNRT-IN-10 exhibits good pharmacokinetic properties and favorable safety profiles. NNRT-IN-10 can be used for the study of AIDS, caused by HIV-1[1].
CAS Number
[2459751-62-1]
UNSPSC
12352005
Target
Cytochrome P450; HIV; Potassium Channel; Reverse Transcriptase
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C(C=CC=N3)C3=NC(NC4CCN(CC5=CC=C(S(C)(=O)=O)C=C5)CC4)=N2
Molecular Formula
C31H32N6O3S
Molecular Weight
568.69
References & Citations
[1]Li W, et al. A nanoparticle-encapsulated non-nucleoside reverse-transcriptase inhibitor with enhanced anti-HIV-1 activity and prolonged circulation time in plasma. Curr Pharm Des. 2015;21 (7) :925-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1A2; CYP2C19; CYP2C9; CYP2D6; HIV-1

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