NNRT-IN-10

• Description :

  NNRT-IN-10 is a potent, selective and orally active non-nucleoside HIV-1 reverse transcriptase (NNRTI) inhibitor with with an EC50 values ranging from 1.16 to 18.3 nM for HIV and its mutant strains. NNRT-IN-10 exhibits good pharmacokinetic properties and favorable safety profiles. NNRT-IN-10 can be used for the study of AIDS, caused by HIV-1[1].

• UNSPSC :

  12352005

• Target :

  Cytochrome P450; HIV; Potassium Channel; Reverse Transcriptase

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Smiles :

  CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C(C=CC=N3)C3=NC(NC4CCN(CC5=CC=C(S(C)(=O)=O)C=C5)CC4)=N2

• Molecular Formula :

  C31H32N6O3S

• Molecular Weight :

  568.69

• References & Citations :

  [1]Li W, et al. A nanoparticle-encapsulated non-nucleoside reverse-transcriptase inhibitor with enhanced anti-HIV-1 activity and prolonged circulation time in plasma. Curr Pharm Des. 2015;21 (7) :925-35.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CYP1A2; CYP2C19; CYP2C9; CYP2D6; HIV-1

• CAS Number :

  [2459751-62-1]