NNRT-IN-11

• Description :

  NNRT-IN-11 (14l) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor with EC50 values of 6.50 to 52.9 nM against WT and a panel of HIV-1 mutants. NNRT-IN-11 has antiviral activity[1].

• UNSPSC :

  12352005

• Target :

  HIV

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Smiles :

  FC1=C(C=CC(NC2=NC=C(C3=COC=C3)C(OC4=C(C=C(C=C4C)/C=C/C#N)C)=N2)=C1)C#N

• Molecular Formula :

  C26H18FN5O2

• Molecular Weight :

  451.45

• References & Citations :

  [1]Zhou Z, et al. Further exploring the tolerant region II: Identification of 2,4,5-trisubstituted pyrimidines as HIV-1 reverse transcriptase allosteric inhibitors with desirable antiviral activities and reduced cytotoxicity. Eur J Med Chem. 2025 Nov 5;297:117992.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported