NNRT-IN-8

• Description :

  NNRT-IN-8 (compound 9K) is a potent non-nucleoside reverse transcriptase inhibitor with EC50 values of 0.0014, 0.0041, 0.0077 µM for WT HIV-1, K103N, E138K, respectively[1].

• UNSPSC :

  12352005

• Target :

  HIV; Reverse Transcriptase

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  CC1=CC(/C=C/C#N)=CC(C)=C1OC2=CC=NC(NC3=CC=C(C=C3)CN4CCN(CC4)C=O)=N2

• Molecular Formula :

  C27H28N6O2

• Molecular Weight :

  468.55

• References & Citations :

  [1]Ji X, et al. Discovery of novel diarypyrimidine derivatives as potent HIV-1 NNRTIs by exploiting the tolerant region I within NNRTI binding pocket. Eur J Med Chem. 2025 Oct 5;295:117787.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HIV-1