NNRT-IN-4

CAT: 0931-T210051-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T210051-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Potassium Channel, HIV Protease, Reverse Transcriptase

Related Pathways

Microbiology/Virology, Membrane transporter/Ion channel, Proteases/Proteasome

Bioactivity

NNRT-IN-4 (Compound 10p) is an inhibitor of non-nucleoside reverse transcriptase (NNRT) with an IC50 of 0.713 μM for HIV-1RT. It exhibits antiviral activity against both wild-type and mutant strains of HIV-1, with an EC50 ranging from 6 to 63 nM. NNRT-IN-4 shows weak inhibitory activity on hERG (IC50=25.9 μM) and CYP enzymes (IC50>50 μM) . In mice, NNRT-IN-4 demonstrates good tolerance and safety at 2 g/kg.

Molecular Formula

C36H38N6O4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-162720	NNRT-IN-4
HY-175519	NNRT-IN-11
GTR19274853-01	NNRT-IN-15
GTR19263667-01	NNRT-IN-9
GTR19263272-01	NNRT-IN-10
HY-149928	NNRT-IN-1
GTR19273083-01	NNRT-IN-12
GTR19263583-01	NNRT-IN-8
HY-178923	NNRT-IN-14
HY-172408	NNRT-IN-6

NNRT-IN-4

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