NNRT-IN-9

• Description :

  NNRT-IN-9 (Compound EG28) is a non-nucleoside reverse transcriptase (NNRT) inhibitor. NNRT-IN-9 has potent antiviral and anti-resistance activity against wild-type (WT) HIV-1 and various clinically relevant mutations (E138K and K103N + Y181C) with EC50s of 55, 67 and 3910 nM, respectively. NNRT-IN-9 can be used for acquired immune deficiency syndrome (AIDS) research[1].

• UNSPSC :

  12352005

• Target :

  HIV; Reverse Transcriptase

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Smiles :

  N#CC1=CC(N2C(N(CC3=CC=CC=C32)CC4=NNC5=NC=CC=C45)=O)=CC=C1

• Molecular Formula :

  C22H16N6O

• Molecular Weight :

  380.40

• References & Citations :

  [1]Goffin E, et al. Discovery and SAR exploration of novel nanomolar 3,4-dihydroquinazolin-2 (1H) -one non-nucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2025 May 29;296:117818.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HIV-1