NNRT-IN-6

CAT: 0804-HY-172408Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172408Size:1 Each
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NNRT-IN-6 (Compound 13a) is the non-nucleoside reverse transcriptase inhibitor (NNRT) for HIV-1 reverse transcriptase (HIV-1 RT) with IC50 of 0.41 μM. NNRT-IN-6 inhibits HIV-1 wildtype and mutant strains L100I, K103N, Y181C, Y188L, E138K, F227L/V106A and RES056 with EC50 of 6.2-250 nM[1].
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
N#CC1=CC(NC2=NC=C(C3=CC=C(N)N=C3)C(OC4=C(C)C=C(/C=C/C#N)C=C4C)=N2)=CC=C1N5CCN(S(=O)(C)=O)CC5
Molecular Formula
C32H31N9O3S
Molecular Weight
621.71
References & Citations
[1]Zhou Z, et al., Structure-based design of novel 2,4,5-trisubstituted pyrimidine derivatives as potent HIV-1 NNRTIs by exploiting the tolerant regions in NNTRIs binding pocket. Eur J Med Chem. 2025 Feb 27;289:117464.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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