NNRT-IN-6

• Description :

  NNRT-IN-6 (Compound 13a) is the non-nucleoside reverse transcriptase inhibitor (NNRT) for HIV-1 reverse transcriptase (HIV-1 RT) with IC50 of 0.41 μM. NNRT-IN-6 inhibits HIV-1 wildtype and mutant strains L100I, K103N, Y181C, Y188L, E138K, F227L/V106A and RES056 with EC50 of 6.2-250 nM[1].

• UNSPSC :

  12352005

• Target :

  HIV; Reverse Transcriptase

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  N#CC1=CC(NC2=NC=C(C3=CC=C(N)N=C3)C(OC4=C(C)C=C(/C=C/C#N)C=C4C)=N2)=CC=C1N5CCN(S(=O)(C)=O)CC5

• Molecular Formula :

  C32H31N9O3S

• Molecular Weight :

  621.71

• References & Citations :

  [1]Zhou Z, et al., Structure-based design of novel 2,4,5-trisubstituted pyrimidine derivatives as potent HIV-1 NNRTIs by exploiting the tolerant regions in NNTRIs binding pocket. Eur J Med Chem. 2025 Feb 27;289:117464.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported