NNRT-IN-4

CAT: 0804-HY-162720Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-162720Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
NNRT-IN-4 (Compound 10p) is an inhibitor for non-nucleoside reverse transcriptase (NNRT) with an IC50 of 0.713 µM for HIV-1 RT. NNRT-IN-4 exhibits antiviral efficacy, inhibits HIV-1 wildtype and mutant strains with EC50 of 6-63 nM. NNRT-IN-4 exhibits a slight inhibitory activities against hERG (IC50=25.9 µM) and CYP enzymes (IC50>50 µM) . NNRT-IN-4 exhibits good tolerability and safety in mice (2 g/kg) [1].
UNSPSC
12352211
Target
HIV; Potassium Channel; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nnrt-in-4.html
Smiles
CC1=C(OC2=C(C(OCC)=O)C=NC(NC3CCN(CC4=CC=C(C(NC)=O)C=C4)CC3)=N2)C(C)=CC(C5=CC=C(C#N)C=C5)=C1
Molecular Formula
C36H38N6O4
Molecular Weight
618.72
References & Citations
[1]Huang WJ, et al., Structure-based discovery of novel piperidine-biphenyl-DAPY derivatives as non-nucleoside reverse transcriptase inhibitors featuring improved potency, safety, and selectivity: From piperazine-biphenyl-DAPYs to piperidine-biphenyl-DAPYs. Eur J Med Chem. 2024 Jul 10;276:116668.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-175519NNRT-IN-11
HY-178923NNRT-IN-14
HY-174417NNRT-IN-10
HY-174303NNRT-IN-9
HY-172408NNRT-IN-6
HY-149928NNRT-IN-1
HY-163110NNRT-IN-2
HY-169207NNRT-IN-5
HY-149338NNRT-IN-3
HY-178341NNRT-IN-13

Alternative Products

CatalogName
MF-0117451-01NNRT-IN-4
MF-0118417-01NNRT-IN-9
MF-0118342-01NNRT-IN-8
MF-0142752-01NNRT-IN-5
MF-0119468-01NNRT-IN-11
MF-0121053-01NNRT-IN-2
MF-0117982-01NNRT-IN-10
MF-0114009-01NNRT-IN-6
OR1011275-014,4',4'',4'''-Methanetetrayltetraphenol
PC52154,4,4,4',4',4'-Hexafluorovaline hydrochloride

Popular Products