NNRT-IN-4

• Description :

  NNRT-IN-4 (Compound 10p) is an inhibitor for non-nucleoside reverse transcriptase (NNRT) with an IC50 of 0.713 µM for HIV-1 RT. NNRT-IN-4 exhibits antiviral efficacy, inhibits HIV-1 wildtype and mutant strains with EC50 of 6-63 nM. NNRT-IN-4 exhibits a slight inhibitory activities against hERG (IC50=25.9 µM) and CYP enzymes (IC50>50 µM) . NNRT-IN-4 exhibits good tolerability and safety in mice (2 g/kg) [1].

• UNSPSC :

  12352211

• Target :

  HIV; Potassium Channel; Reverse Transcriptase

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/nnrt-in-4.html

• Smiles :

  CC1=C(OC2=C(C(OCC)=O)C=NC(NC3CCN(CC4=CC=C(C(NC)=O)C=C4)CC3)=N2)C(C)=CC(C5=CC=C(C#N)C=C5)=C1

• Molecular Formula :

  C36H38N6O4

• Molecular Weight :

  618.72

• References & Citations :

  [1]Huang WJ, et al., Structure-based discovery of novel piperidine-biphenyl-DAPY derivatives as non-nucleoside reverse transcriptase inhibitors featuring improved potency, safety, and selectivity: From piperazine-biphenyl-DAPYs to piperidine-biphenyl-DAPYs. Eur J Med Chem. 2024 Jul 10;276:116668.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported