WP-1130

CAT: 0026-2014-5Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0026-2014-5Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Cell-permeable. WP1130 acts as a partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function. WP1130-mediated inhibition of tumor-activated DUBs results in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL-1 and p53. Blocks JAK2 signaling via JAK2 ubiquitination.

Shipping Conditions

gel pack

Storage Conditions

-20°C

Shelf Life

24months

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WP-1130

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