NNRT-IN-13

• Description :

  NNRT-IN-13 is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor that directly inhibiting HIV-1 reverse transcriptase (IC₅₀ = 0.25 μM) . NNRT-IN-13 exhibits excellent antiviral activity against wild-type HIV-1 (EC₅₀ = 0.0046 μM) and a broad spectrum of drug-resistant mutants. NNRT-IN-13 exhibits favorable in vivo metabolic and safety profiles. NNRT-IN-13 can be used for human immunodeficiency virus (HIV) research[1].

• UNSPSC :

  12352005

• Target :

  HIV; Reverse Transcriptase

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  O=S(C1=CC=C(CN2CCC(NC3=NC(OC4=C(C=C(C=C4C)/C=C/C#N)C)=CC(NCC5=COC=N5)=N3)CC2)C=C1)(N)=O

• Molecular Formula :

  C31H34N8O4S

• Molecular Weight :

  614.72

• References & Citations :

  [1]Ji X, et al. Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles. J Med Chem. 2025 Oct 9;68 (19) :20519-20535.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported