NNRT-IN-12

• Description :

  NNRT-IN-12 (compound 19) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC50 value of 0.107 μM for WT HIV-1 RT. NNRT-IN-12 shows anti-HIV-1 activity with EC50 value of 14.1, 5.03, 7.64, 27.1 nM for L100I, K103N, Y181C, Y188L mutant HIV-1 strains, respectively. NNRT-IN-12 shows cytotoxicity[1].

• UNSPSC :

  12352100

• Target :

  HIV; Reverse Transcriptase

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  O=C(N)C1=CC=C(CN2CC(F)(F)C(NC3=NC(OC4=C(C)C=C(/C=C/C#N)C=C4C)=C5C(C=CS5)=N3)CC2)C=C1

• Molecular Formula :

  C30H28F2N6O2S

• Molecular Weight :

  574.64

• References & Citations :

  [1]Zhou Z, et al. Structure-Based Drug Design Yields Diarylpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. ACS Infect Dis. 2025 Aug 6.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HIV-1