AR Degrader-2

AR Degrader-2

• CAS Number: 3023359-76-1
• UNSPSC Description: AR Degrader-2 (Compound 2) is a molecular glue that degrades androgen receptor (AR) with a DC50 of 0.3-0.5 μM in cell VCaP.
• Target Antigen: Androgen Receptor; Molecular Glues
• Type: Reference compound
• Related Pathways: PROTAC;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ar-degrader-2.html
• Smiles: CC(C)([C@H](C1(C)C)NC(C2=CC=C(N3CCC(CC3)C(N4CCN(CC4)C(/C(C#N)=C/C(C)(C)C)=O)=O)C=C2)=O)[C@H]1OC5=CC(Cl)=C(C=C5)C#N
• Molecular Weight: 713.31
• References & Citations: [1]Testa A, et al., Bifunctional molecules for targeted protein degradation. WO2023242598A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported