AR Degrader-2

• UNSPSC Description:

  AR Degrader-2 (Compound 2) is a molecular glue that degrades androgen receptor (AR) with a DC50 of 0.3-0.5 μM in cell VCaP.

• Target Antigen:

  Androgen Receptor; Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ar-degrader-2.html

• Smiles:

  CC(C)([C@H](C1(C)C)NC(C2=CC=C(N3CCC(CC3)C(N4CCN(CC4)C(/C(C#N)=C/C(C)(C)C)=O)=O)C=C2)=O)[C@H]1OC5=CC(Cl)=C(C=C5)C#N

• Molecular Weight:

  713.31

• References & Citations:

  [1]Testa A, et al., Bifunctional molecules for targeted protein degradation. WO2023242598A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3023359-76-1