AR Degrader-2

CAT: 0804-HY-163813Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-163813Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

AR Degrader-2 (Compound 2) is a molecular glue that degrades androgen receptor (AR) with a DC50 of 0.3-0.5 μM in cell VCaP.

CAS Number

3023359-76-1

UNSPSC

12352005

Target

Androgen Receptor; Molecular Glues

Type

Reference compound

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ar-degrader-2.html

Smiles

CC(C)([C@H](C1(C)C)NC(C2=CC=C(N3CCC(CC3)C(N4CCN(CC4)C(/C(C#N)=C/C(C)(C)C)=O)=O)C=C2)=O)[C@H]1OC5=CC(Cl)=C(C=C5)C#N

Molecular Formula

C40H49ClN6O4

Molecular Weight

713.31

References & Citations

[1]Testa A, et al., Bifunctional molecules for targeted protein degradation. WO2023242598A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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