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PROTAC AR Degrader-9

CAT: 0804-HY-170448Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170448Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor, that degrades AR in human hair follicle papilla cells (HDPCs) with a DC50 of 262.38 nM. PROTAC AR Degrader-9 promotes the expressions of paracrine factors, such as TGF-β1 and β-catenin, exhibits hair regenerating efficacy in mouse models[1]. (Pink: ligand for target protein AR ligand-38 ; Black: linker; Blue: ligand for E3 ligase Cereblon (HY-170449) )
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Smiles
O=C(N[C@H]1CC[C@H](OC2=CC(Cl)=C(C#N)C=C2)CC1)C3=CC=C(C4CCN(CC5CCCN(C5)C6=CC=C(C=C6)C(NC7CCC(NC7=O)=O)=O)CC4)C=C3
Molecular Formula
C43H49ClN6O5
Molecular Weight
765.34
References & Citations
[1]Mao X, et al., Discovery of a Novel Non-invasive AR PROTAC Degrader for the Topical Treatment of Androgenetic Alopecia. J Med Chem. 2024 Dec 26;67 (24) :22218-22244.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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