AR Degrader-1

AR Degrader-1

• UNSPSC Description: AR Degrader-1 (Compound ML 2-9) is a molecular glue androgen receptor (AR) monovalent degrader. AR Degrader-1 degrades AR through DCAF16 (E3 ligase) without obvious cytotoxicity in LNCaP prostate cancer cells[1].
• Target Antigen: Androgen Receptor; E1/E2/E3 Enzyme; Molecular Glues
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PROTAC;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ar-degrader-1.html
• Smiles: O=C(C1=NN=C(N2CCN(S(=O)(C=C)=O)CC2)C=C1)N[C@H]3CC[C@H](OC4=CC=C(C#N)C(Cl)=C4)CC3
• Molecular Weight: 531.03
• References & Citations: [1]Melissa Lim, et al. DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders. ACS Central Science. DOI: 10.1021/acscentsci.4c00286
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported