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PROTAC AR Degrader-10

CAT: 0804-HY-173372Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173372Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC AR Degrader-10 (GT19) is a protein degrader targeting the androgen receptor (AR) with a DC50 value ≤100 nM. PROTAC AR Degrader-10 can be used for prostate cancer study. (Structure Note: Pink: target protein ligand ; Blue: E3 ligase ligand (HY-138793) ; Black: linker).
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC1=C(C#N)C=CC(O[C@H]2C(C)(C)[C@H](NC(C3=CC=C(N4CCN(CCCSC5=CC=C(C(N(C6C(NC(CC6)=O)=O)C7)=O)C7=C5)CC4)N=C3)=O)C2(C)C)=C1
Molecular Formula
C41H46ClN7O5S
Molecular Weight
784.37
References & Citations
[1]Zhang L, et al. Predicting PROTAC-targeted Degradation and Designing Androgen Receptor Degraders with AiPROTAC. Posted March 02, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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