PROTAC AR Degrader-7

PROTAC AR Degrader-7

• CAS Number: 2505495-83-8
• UNSPSC Description: PROTAC AR Degrader-7 (compound 99) is a PROTAC targeting androgen receptor with an IC50 value of 3 nM. PROTAC AR Degrader-7 is composed of PROTAC target protein ligand AR ligand-32 (HY-170303) (red part), E3 ligase ligand E3 ligase Ligand 44 (HY-170304) (blue part) and PROTAC Linker N-Boc-piperazine (HY-30105) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 145 (HY-170305)[1].
• Target Antigen: Androgen Receptor; PROTACs
• Type: Reference compound
• Related Pathways: PROTAC;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/androgen-receptor-degrader-4.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=NC=C(N2CCN(C[C@@H]3[C@]4([H])[C@@]3([H])CN(C5=CC6=C(C(N(C7CCC(NC7=O)=O)C6=O)=O)C=C5F)C4)CC2)N=C1)N[C@H]8CC[C@H](OC9=CC=C(C#N)C(Cl)=C9)CC8
• Molecular Weight: 810.27
• References & Citations: [1]DU wu,et al. Dual-function chimeric heterocyclic compound for targeted degradation of androgen receptor and application thereof. CN111825657A. 2020.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported