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PROTAC AR Degrader-7

CAT: 0804-HY-160221Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-160221Size:1 Each
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Description
PROTAC AR Degrader-7 (compound 99) is a PROTAC targeting androgen receptor with an IC50 value of 3 nM. PROTAC AR Degrader-7 is composed of PROTAC target protein ligand AR ligand-32 (red part), E3 ligase ligand E3 ligase Ligand 44 (HY-170304) (blue part) and PROTAC Linker N-Boc-piperazine (HY-30105) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 145 (HY-170305).
CAS Number
2505495-83-8
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/androgen-receptor-degrader-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC=C(N2CCN(C[C@@H]3[C@]4([H])[C@@]3([H])CN(C5=CC6=C(C(N(C7CCC(NC7=O)=O)C6=O)=O)C=C5F)C4)CC2)N=C1)N[C@H]8CC[C@H](OC9=CC=C(C#N)C(Cl)=C9)CC8
Molecular Formula
C41H41ClFN9O6
Molecular Weight
810.27
References & Citations
[1]DU wu, et al. Dual-function chimeric heterocyclic compound for targeted degradation of androgen receptor and application thereof. CN111825657A. 2020.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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