PROTAC AR Degrader-5

• UNSPSC Description:

  PROTAC AR Degrader-5 (compound A46) is a potent AR PROTACs degrader with an IC50 value of 49 nM. PROTAC AR Degrader-5 inhibits sebaceous plaque and induces hair regeneration (Pink: ligand for target protein (HY-169967); black: linker (HY-169966); Blue: E3 ligase ligand (HY-125845))[1].

• Target Antigen:

  Androgen Receptor; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/protac-ar-degrader-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  S=C1N(C2=C(C(C(F)(F)F)=C(C=C2)C#N)F)C(C(C)(N1C3=CN=C(C4=CC=C(C=C4)OCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)C=C3)C)=O

• Molecular Weight:

  1043.16

• References & Citations:

  [1]YouZhi Tong, et al. Bifunctional compound, preparation method therefor, and use thereof. WO2021180160A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2703021-51-4