PROTAC AR Degrader-5

PROTAC AR Degrader-5

• CAS Number: 2703021-51-4
• UNSPSC Description: PROTAC AR Degrader-5 (compound A46) is a potent AR PROTACs degrader with an IC50 value of 49 nM. PROTAC AR Degrader-5 inhibits sebaceous plaque and induces hair regeneration (Pink: ligand for target protein (HY-169967); black: linker (HY-169966); Blue: E3 ligase ligand (HY-125845))[1].
• Target Antigen: Androgen Receptor; PROTACs
• Type: Reference compound
• Related Pathways: PROTAC;Vitamin D Related/Nuclear Receptor
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/protac-ar-degrader-5.html
• Solubility: 10 mM in DMSO
• Smiles: S=C1N(C2=C(C(C(F)(F)F)=C(C=C2)C#N)F)C(C(C)(N1C3=CN=C(C4=CC=C(C=C4)OCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)C=C3)C)=O
• Molecular Weight: 1043.16
• References & Citations: [1]YouZhi Tong, et al. Bifunctional compound, preparation method therefor, and use thereof. WO2021180160A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported