PROTAC AR/AR-V7 degrader-1

• UNSPSC Description:

  PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker)[1].

• Target Antigen:

  Adrenergic Receptor; Apoptosis; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;GPCR/G Protein;Neuronal Signaling;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-ar-ar-v7-degrader-1.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C1C(C)(C)N(CCNC2=C(C=CC=N3)C3=C(F)C=C2)C(N1C4=CC(C(F)(F)F)=C(C#N)C=C4)=O

• Molecular Weight:

  485.43

• References & Citations:

  [1]Maoxu Xiao, et al. Structure–Activity Relationship (SAR) Studies of Novel Monovalent AR/AR-V7 Dual Degraders with Potent Efficacy against Advanced Prostate Cancer. J. Med. Chem. 2024, 67, 7, 5567-5590.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2841308-96-9