α1A-AR Degrader 9c

α1A-AR Degrader 9c

• CAS Number: 2863635-02-1
• UNSPSC Description: α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC50 of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC50 of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research[1].
• Target Antigen: Adrenergic Receptor; PROTACs
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/α1a-ar-degrader-9c.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCN4N=NC(C(N5CCN(C6=NC(N)=C7C=C(OC)C(OC)=CC7=N6)CC5)=O)=C4
• Molecular Weight: 829.82
• References & Citations: [1]Li Z, et al. First small-molecule PROTACs for G protein-coupled receptors: inducing α1A-adrenergic receptor degradation. Acta Pharm Sin B. 2020 Sep;10(9):1669-1679.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported