α1A-AR Degrader 9c

• UNSPSC Description:

  α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC50 of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC50 of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research[1].

• Target Antigen:

  Adrenergic Receptor; PROTACs

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/α1a-ar-degrader-9c.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCN4N=NC(C(N5CCN(C6=NC(N)=C7C=C(OC)C(OC)=CC7=N6)CC5)=O)=C4

• Molecular Weight:

  829.82

• References & Citations:

  [1]Li Z, et al. First small-molecule PROTACs for G protein-coupled receptors: inducing α1A-adrenergic receptor degradation. Acta Pharm Sin B. 2020 Sep;10(9):1669-1679.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2863635-02-1