BRD4 degrader-2

• Target :

  Molecular Glues|||Epigenetic Reader Domain|||E1/E2/E3 Enzyme

• Related Pathways :

  Chromatin/Epigenetic|||PROTAC|||Ubiquitination

• Bioactivity :

  BRD4 degrader-2 (Compound JP-2-197) is a covalent and monovalent molecule glue-type BRD4 degrader. It targets RNF126 (E3 ligase) to degrade both long and short isoforms of BRD4 in cells.

• Smiles :

  CC=1C2=C(N3C([C@H](CC(=O)N4CCN(C(/C=C/C(=O)C5=CC=C(OC)C=C5)=O)CC4)N=C2C6=CC=C(Cl)C=C6)=NN=C3C)SC1C

• Molecular Formula :

  C34H33ClN6O4S

• Molecular Weight :

  657.18

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3036530-43-2