BRD4 degrader-2

• Target:

  Molecular Glues|||Epigenetic Reader Domain|||E1/E2/E3 Enzyme

• Related Pathways:

  Chromatin/Epigenetic|||PROTAC|||Ubiquitination

• Bioactivity:

  BRD4 degrader-2 (Compound JP-2-197) is a covalent and monovalent molecule glue-type BRD4 degrader. It targets RNF126 (E3 ligase) to degrade both long and short isoforms of BRD4 in cells.

• Smiles:

  CC=1C2=C (N3C ([C@H] (CC (=O) N4CCN (C (/C=C/C (=O) C5=CC=C (OC) C=C5) =O) CC4) N=C2C6=CC=C (Cl) C=C6) =NN=C3C) SC1C

• Molecular Formula:

  C34H33ClN6O4S

• Molecular Weight:

  657.18

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3036530-43-2