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BRD4 degrader-2

CAT: 0931-T209911-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209911-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3036530-43-2
Target
Molecular Glues, Epigenetic Reader Domain, E1/E2/E3 Enzyme
Related Pathways
Chromatin/Epigenetic, PROTAC, Ubiquitination
Bioactivity
BRD4 degrader-2 (Compound JP-2-197) is a covalent and monovalent molecule glue-type BRD4 degrader. It targets RNF126 (E3 ligase) to degrade both long and short isoforms of BRD4 in cells.
Smiles
CC=1C2=C(N3C([C@H](CC(=O)N4CCN(C(/C=C/C(=O)C5=CC=C(OC)C=C5)=O)CC4)N=C2C6=CC=C(Cl)C=C6)=NN=C3C)SC1C
Molecular Formula
C34H33ClN6O4S
Molecular Weight
657.18
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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