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ALK degrader 2

CAT: 0013-GTR19265324-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19265324-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALK degrader 2 is an orally active ALK degrader that reduces EML4-ALK protein levels (DC50= 8 nM) and nucleophosmin (NPM) -ALK protein levels (DC50= 102 nM) . It facilitates ALK degradation through the Hsp70 chaperone system and the ubiquitin-proteasome pathway. In H3122 cells, ALK degrader 2 causes significant cell cycle arrest at the S phase and induces apoptosis. Additionally, it demonstrates antitumor activity in mice with H3122 xenograft tumors. ALK degrader 2 is a useful compound in researching non-small cell lung cancer (NSCLC) .
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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