ALK5-IN-32

• UNSPSC Description:

  ALK5-IN-32 (compound EX-09) is a selective ALK-5 inhibitor (10 nMIC50TGF-β-induced SMAD signaling. ALK5-IN-32 has the potential to inhibit growth of tumour in vivo. ALK5-IN-32 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1].

• Target Antigen:

  TGF-beta/Smad; TGF-β Receptor

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt;TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/alk5-in-32.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC=CC2=C(NC3=NC(NC4=CC=C(N5CCNCC5)C=C4)=NC=C3F)C=NN=C12

• Molecular Weight:

  430.48

• References & Citations:

  [1]Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2785430-88-6