ALK5-IN-9

• Description:

  ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI (ALK5) . ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease[1].

• UNSPSC:

  12352005

• Target:

  TGF-β Receptor

• Type:

  Reference compound

• Related Pathways:

  TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/alk5-in-9.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OCCN1CCN(C2=CC=C(NC3=NC=CC(OC4=CN(C5CC5)N=C4C6CCOCC6)=C3)C=C2C(F)(F)F)CC1

• Molecular Formula:

  C29H35F3N6O3

• Molecular Weight:

  572.62

• References & Citations:

  [1]Wang Z, et al. Synthesis and biological evaluation of 4- (pyridine-4-oxy) -3- (tetrahydro-2H-pyran-4-yl) -pyrazole derivatives as novel, potent of ALK5 receptor inhibitors. Bioorg Med Chem Lett. 2022;61:128552.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2489611-06-3]