Products for Research Use Only
RegisterLogin

ALK5-IN-9

CAT: 0804-HY-144437Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-144437Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI (ALK5) . ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease[1].
CAS Number
2489611-06-3
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk5-in-9.html
Solubility
10 mM in DMSO
Smiles
OCCN1CCN(C2=CC=C(NC3=NC=CC(OC4=CN(C5CC5)N=C4C6CCOCC6)=C3)C=C2C(F)(F)F)CC1
Molecular Formula
C29H35F3N6O3
Molecular Weight
572.62
References & Citations
[1]Wang Z, et al. Synthesis and biological evaluation of 4- (pyridine-4-oxy) -3- (tetrahydro-2H-pyran-4-yl) -pyrazole derivatives as novel, potent of ALK5 receptor inhibitors. Bioorg Med Chem Lett. 2022;61:128552.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-151273ALK5-IN-27
HY-142949ALK5-IN-7
HY-163507ALK5-IN-79
HY-162902ALK5-IN-82
HY-142950ALK5-IN-6
HY-151282ALK5-IN-32
HY-178231ALK5-IN-85
HY-168607ALK5-IN-83
HY-151277ALK5-IN-29
HY-151283ALK5-IN-33

Alternative Products

CatalogName
T64051-01ALK5-IN-9
103-M96ALK5
BA9089-5.1ALK5-IN-34
BA9158-10ALK5-IN-8
T62394-01ALK5-IN-31
T63114-01ALK5-IN-7
70R-50476ALK5 antibody
MBS5805228ALK5-IN-27
GTR19185980-01ALK5-IN-26
GTR19235686-01ALK5-IN-79

Popular Products