ALK5-IN-7

• Description :

  ALK5-IN-7 is a potent inhibitor of ALK5. Transforming growth factor beta (TGF-β) is a multifunctional cytokine that is involved in regulating cell proliferation, differentiation and apoptosis through complex receptor signaling pathways on the cell surface in an autocrine, paracrine and endocrine manner. ALK5-IN-7 has the potential for the research of TGF-β-related diseases and conditions, including but not limited to tumors, fibrotic diseases, inflammatory diseases, autoimmune diseases, etc (extracted from patent WO2021129621A1, compound 4) [1].

• CAS Number :

  [2657720-07-3]

• UNSPSC :

  12352005

• Target :

  TGF-β Receptor

• Type :

  Reference compound

• Related Pathways :

  TGF-beta/Smad

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/alk5-in-7.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(C)(C)C1=NC=CC(C2=CC3=NC=CC(OC4=CN(C5CC5)N=C4C6CCOCC6)=C3S2)=C1

• Molecular Formula :

  C26H28N4O3S

• Molecular Weight :

  476.59

• References & Citations :

  [1]Tang Feng, et al. Pyrazoles. Patent WO2021129621A1.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported