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ALK5-IN-27

CAT: 0804-HY-151273Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151273Size:1 Each
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Description
ALK5-IN-27 (Compound EX-04) is a potent ALK-5 inhibitor with an IC50 ≤10 nM. ALK5-IN-27 also inhibits ALK-2 (selectivity ALK2/ALK5 ≤10) [1].
CAS Number
2785430-83-1
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk5-in-27.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(CC2=CC(NC3=NC=CC(NC4=C5C=CC=C(C)C5=NN=C4)=N3)=CC=C2)CC1
Molecular Formula
C25H28N8
Molecular Weight
440.54
References & Citations
[1]Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK2; ALK5

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