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ALK5-IN-82

CAT: 0804-HY-162902Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162902Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALK5-IN-82 is a potent and selective inhibitor against activin receptor-like kinase 5 (ALK5) with an IC50 value of 9.1 nM. ALK5-IN-82 inhibits the protein expression of α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of metalloproteinase 1 (TIMP-1) /matrix metalloproteinase 13 (MMP-13) in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is promising for research of cardiac fibrosis[1].
CAS Number
3001361-04-9
UNSPSC
12352211
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/alk5-in-82.html
Smiles
CC1=NC(C(NC(CNC(CC2=CC=CS2)=O)=N3)=C3C(C=C4)=CN5C4=NC=N5)=CC=C1
Molecular Formula
C22H19N7OS
Molecular Weight
429.50
References & Citations
[1]Yang YX, et al. Synthesis of amide derivatives containing the imidazole moiety and evaluation of their anti-cardiac fibrosis activity. Arch Pharm (Weinheim) . 2024 Aug;357 (8) :e2400131.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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