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ALK5

CAT: 0209-103-M96Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-103-M96Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Most cell types express three sizes of receptors for TGFβ. These are designated Type I (53 kDa), Type II (7085 kDa), and Type III (250-350 kDa) . The Type III receptor, a proteoglycan that exists in membranebound and soluble forms, binds TGFβ1, TGFβ2, and TGFβ3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane bound serine/threonine kinase that binds TGFβ1 and TGFβ3 with high affinity and TGFβ2 with a much lower affinity. The Type I receptor, originally known as ALK5 (Activin receptor-like kinase) is also a membranebound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGFβ. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.
Synonyms
Tgfbr1; ALK5; Alk-5; TbetaRI; AU017191; TbetaR-I
NCBI Gene ID
21812
UniProt
Q64729
Accession Number
NP_033396.1
Accession Number mRNA
NM_009370.2
Chromosomal Location
4 B1; 4 19.3 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recmobinant mouse ALK5 extracellular domain
Clone
(#3A11)
Applications
WB, IHC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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