IDO1/TDO-IN-1

• UNSPSC Description:

  IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].

• Target Antigen:

  Apoptosis; Bcl-2 Family; Indoleamine 2,3-Dioxygenase (IDO)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ido1-tdo-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(OCC1=COC2=C1C(C(C3=C2C=CC4=C3C=CC(C4(C)C)=O)=O)=O)=O

• Molecular Weight:

  364.35

• References & Citations:

  [1]Jiangxin Liu, et al. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. Eur J Med Chem. 2022 May 5;235:114294.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2379527-72-5