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IDO/TDO-IN-1

CAT: 0804-HY-128355-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128355-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1].
CAS Number
2033173-01-0
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ido-tdo-in-1.html
Purity
99.30
Solubility
DMSO : 30 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
CN1N=CC(C2=CC=C(N3CCC([C@@H](C4=C5C=CC=C4F)N6C5=CN=C6)CC3)C=C2)=C1
Molecular Formula
C25H24FN5
Molecular Weight
413.49
References & Citations
[1]Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10 (6) :949-953.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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T11623-01IDO/TDO-IN-1
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