(R)-IDO/TDO-IN-1

• UNSPSC Description:

  (R)-IDO/TDO-IN-1 (compound 25) is an indoleamine-2,3-dioxygenase (IDO) inhibitor, with good pharmacokinetic properties. (R)-IDO/TDO-IN-1 exhibits anti-tumor activity in MC38 xenograft model. (R)-IDO/TDO-IN-1 shows synergistic effect with anti-PD-1 monoclonal antibody (SHR-1210)[1].

• Target Antigen:

  Indoleamine 2,3-Dioxygenase (IDO)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/r-ido-tdo-in-1.html

• Purity:

  98.04

• Solubility:

  DMSO : 10 mg/mL (ultrasonic;adjust pH to 2 with HCl)

• Smiles:

  CN1N=CC(C2=CC=C(N3CCC([C@H](C4=C5C=CC=C4F)N6C5=CN=C6)CC3)C=C2)=C1

• Molecular Weight:

  413.49

• References & Citations:

  [1]Tu W, Yang F, Xu G, Chi J, Liu Z, Peng W, Hu B, Zhang L, Wan H, Yu N, Jin F, Hu Q, Zhang L, He F, Tao W. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  2033173-00-9