BJE6-106

• Target:

  PKC|||Caspase|||Apoptosis|||JNK

• Related Pathways:

  Chromatin/Epigenetic|||Proteases/Proteasome|||Apoptosis|||Cytoskeletal Signaling|||MAPK

• Bioactivity:

  BJE6-106 (B106) is a selective PKC? inhibitor (IC50 = 0.05 ?M) with 1000-fold higher selectivity for PKC? than PKC? (IC50 = 50 ?M) . BJE6-106 induces caspase-dependent apoptosis, activates the JNK pathway and H2AX, and can be used to study NRAS-mutated melanoma.

• Smiles:

  O=CC1=CC(=CC=2C=CC(OC12)(C)C)CCN3C=4C=CC=CC4C=5C=CC=CC53

• Molecular Formula:

  C26H23NO2

• Molecular Weight:

  381.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1564249-38-2