IDO1/TDO-IN-4

IDO1/TDO-IN-4

• CAS Number: 461424-21-5
• UNSPSC Description: IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π?π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders[1].
• Target Antigen: Indoleamine 2,3-Dioxygenase (IDO)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/ido1-tdo-in-4.html
• Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)|Methanol : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: C12=CC=CC=C1NC3=C2C=CN=C3C4=CNC=N4
• Molecular Weight: 234.26
• References & Citations: [1]Yu Zhang, et al. B Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity. J Med Chem. 2022 Aug 7.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported