IDO1/TDO-IN-4

• UNSPSC Description:

  IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π?π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders[1].

• Target Antigen:

  Indoleamine 2,3-Dioxygenase (IDO)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ido1-tdo-in-4.html

• Solubility:

  DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)|Methanol : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  C12=CC=CC=C1NC3=C2C=CN=C3C4=CNC=N4

• Molecular Weight:

  234.26

• References & Citations:

  [1]Yu Zhang, et al. B Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity. J Med Chem. 2022 Aug 7.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  461424-21-5