IDO1/TDO-IN-9

• Target:

  Indoleamine 2,3-Dioxygenase (IDO) |||IDO

• Related Pathways:

  Metabolism

• Bioactivity:

  IDO1/TDO-IN-9 (Compound 66) is a potent dual inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO), with an IC50 value of less than 1 ?M. It effectively inhibits the activity of IDO1 and TDO, preventing the degradation of tryptophan into kynurenine, thereby restoring immune activity in the tumor microenvironment and inhibiting tumor growth. IDO1/TDO-IN-9 shows potential for cancer research.

• Smiles:

  FC1=CC2=C (N=C1Cl) ON=C2N

• Molecular Formula:

  C6H3ClFN3O

• Molecular Weight:

  187.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1878200-88-4