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IDO1/TDO-IN-7

CAT: 0804-HY-162962Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162962Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IDO1/TDO-IN-7 (Compound 43b), an isoquinoline derivative, is a potent dual IDO1/TDO inhibitor, with IC50s of 0.31 μM and 0.08 μM, respectively. IDO1/TDO-IN-7 displays acceptable pharmacokinetic profiles and potent antitumor efficacy with low toxicity in B16-F10 tumor model[1].
UNSPSC
12352211
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ido1-tdo-in-7.html
Smiles
OC1=C2C(C=C(C3=CC=C(NS(=O)(C(F)(F)F)=O)C=C3)N=C2)=CC=C1OC
Molecular Formula
C17H13F3N2O4S
Molecular Weight
398.36
References & Citations
[1]Lin Z, et, al. Discovery, synthesis and biological evaluation of novel isoquinoline derivatives as potent indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase dual inhibitors. Eur J Med Chem. 2024 Sep 12:279:116852.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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