IDO1/TDO-IN-3

IDO1/TDO-IN-3

• CAS Number: 2347579-03-5
• UNSPSC Description: IDO1/TDO-IN-3 is a potent inhibitor of IDO1/TDO. IDO1/TDO-IN-3 exhibits significant activities against IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM). IDO1/TDO-IN-3 shows considerable in vivo anti-tumor activity and no obvious toxicity is observed[1].
• Target Antigen: Indoleamine 2,3-Dioxygenase (IDO)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ido1-tdo-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=CC(F)=CC=C2C(C3=C1N=NN3C4=CC=C(C(Cl)=C4)F)=O
• Molecular Weight: 345.69
• References & Citations: [1]Pan S, et al. Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO). Eur J Med Chem. 2020 Dec 1;207:112703.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported