IDO1/TDO-IN-3

• Description :

  IDO1/TDO-IN-3 is a potent inhibitor of IDO1/TDO. IDO1/TDO-IN-3 exhibits significant activities against IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM) . IDO1/TDO-IN-3 shows considerable in vivo anti-tumor activity and no obvious toxicity is observed[1].

• UNSPSC :

  12352005

• Target :

  Indoleamine 2,3-Dioxygenase (IDO)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ido1-tdo-in-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C2=CC(F)=CC=C2C(C3=C1N=NN3C4=CC=C(C(Cl)=C4)F)=O

• Molecular Formula :

  C16H6ClF2N3O2

• Molecular Weight :

  345.69

• References & Citations :

  [1]Pan S, et al. Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO) . Eur J Med Chem. 2020 Dec 1;207:112703.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2347579-03-5]