IDO1/TDO-IN-2

• Description :

  IDO1/TDO-IN-2 (Compound 1) is a potent inhibitor of IDO1/TDO with IC50s of 0.1 and 0.07 μM. IDO1/TDO-IN-2 has the potential for the research of cancer diseases[1].

• UNSPSC :

  12352005

• Target :

  Indoleamine 2,3-Dioxygenase (IDO)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ido1-tdo-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C2=CC=CC=C2C(C3=C1N=NN3C4=CC=CC=C4)=O

• Molecular Formula :

  C16H9N3O2

• Molecular Weight :

  275.26

• References & Citations :

  [1]Pan S, et al. Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO) . Eur J Med Chem. 2020 Dec 1;207:112703.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [5466-47-7]