IDO1/TDO-IN-8

• Target:

  Indoleamine 2,3-Dioxygenase (IDO) |||IDO

• Related Pathways:

  Metabolism

• Bioactivity:

  IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor capable of crossing the blood-brain barrier, with EC50 values of 0.33 ?M and 1.78 ?M, respectively. It modulates the kynurenine pathway of tryptophan metabolism, reducing the kynurenine/tryptophan ratio. IDO1/TDO-IN-8 has neuroprotective effects, alleviating motor dysfunction and improving depressive behavior, making it relevant for research into Parkinson's disease with comorbid depression.

• Smiles:

  CC1=CC (C2=NC=CC3=C2NC4=CC=CC=C43) =C (C) S1

• Molecular Formula:

  C17H14N2S

• Molecular Weight:

  278.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C