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IDO1/TDO-IN-8

CAT: 0931-T207127-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207127-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Indoleamine 2,3-Dioxygenase (IDO), IDO
Related Pathways
Metabolism
Bioactivity
IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor capable of crossing the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. It modulates the kynurenine pathway of tryptophan metabolism, reducing the kynurenine/tryptophan ratio. IDO1/TDO-IN-8 has neuroprotective effects, alleviating motor dysfunction and improving depressive behavior, making it relevant for research into Parkinson's disease with comorbid depression.
Smiles
CC1=CC(C2=NC=CC3=C2NC4=CC=CC=C43)=C(C)S1
Molecular Formula
C17H14N2S
Molecular Weight
278.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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