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IDO1/TDO-IN-8

CAT: 0804-HY-173513Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173513Size:1 Each
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Description
IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor that can penetrate the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. IDO1/TDO-IN-8 reduces the kynurenine/tryptophan ratio by regulating the kynurenine pathway of tryptophan metabolism. IDO1/TDO-IN-8 has a neuroprotective effect and can alleviate motor dysfunction and improve depressive behavior. IDO1/TDO-IN-8 can be used in the study of Parkinson's disease combined with depression[1].
CAS Number
3085413-22-2
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO)
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CC1=CC(C2=NC=CC3=C2NC4=C3C=CC=C4)=C(C)S1
Molecular Formula
C17H14N2S
Molecular Weight
278.37
References & Citations
[1]Chen X, et al. Proof of concept study for developing 1-thienyl-β-carboline derivatives as IDO1 and TDO dual inhibitors to treat Parkinson's disease complicating depression. Eur J Med Chem. 2025 Jul 5;291:117597.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDO1

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