ALK5-IN-82

• Target:

  TGF-beta/Smad|||Others

• Related Pathways:

  Stem Cells|||Others

• Bioactivity:

  ALK5-IN-82 is a potent and selective inhibitor of activin receptor-like kinase 5 (ALK5), demonstrating an IC50 value of 9.1 nM. This compound effectively suppresses the expression of ?-smooth muscle actin (?-SMA), collagen I, and the proteinases tissue inhibitor of metalloproteinase 1 (TIMP-1) and matrix metalloproteinase 13 (MMP-13) in human umbilical vein endothelial cells induced by transforming growth factor-?. ALK5-IN-82 shows potential for use in research related to cardiac fibrosis.

• Smiles:

  O=C (NCC1=NC (C2=NC (=CC=C2) C) =C (N1) C=3C=CC4=NC=NN4C3) CC=5SC=CC5

• Molecular Formula:

  C22H19N7OS

• Molecular Weight:

  429.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3001361-04-9