ALK5-IN-82

CAT: 0931-MF-0062559-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0062559-01Size:25 mg
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CAS Number
3001361-04-9
Target
TGF-beta/Smad|||Others
Related Pathways
Stem Cells|||Others
Bioactivity
ALK5-IN-82 is a potent and selective inhibitor of activin receptor-like kinase 5 (ALK5), demonstrating an IC50 value of 9.1 nM. This compound effectively suppresses the expression of ?-smooth muscle actin (?-SMA), collagen I, and the proteinases tissue inhibitor of metalloproteinase 1 (TIMP-1) and matrix metalloproteinase 13 (MMP-13) in human umbilical vein endothelial cells induced by transforming growth factor-?. ALK5-IN-82 shows potential for use in research related to cardiac fibrosis.
Smiles
O=C(NCC1=NC(C2=NC(=CC=C2)C)=C(N1)C=3C=CC4=NC=NN4C3)CC=5SC=CC5
Molecular Formula
C22H19N7OS
Molecular Weight
429.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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