ALK5-IN-82

• CAS Number :

  3001361-04-9

• Target :

  TGF-beta/Smad|||Others

• Related Pathways :

  Stem Cells|||Others

• Bioactivity :

  ALK5-IN-82 is a potent and selective inhibitor of activin receptor-like kinase 5 (ALK5), demonstrating an IC50 value of 9.1 nM. This compound effectively suppresses the expression of ?-smooth muscle actin (?-SMA), collagen I, and the proteinases tissue inhibitor of metalloproteinase 1 (TIMP-1) and matrix metalloproteinase 13 (MMP-13) in human umbilical vein endothelial cells induced by transforming growth factor-?. ALK5-IN-82 shows potential for use in research related to cardiac fibrosis.

• Smiles :

  O=C(NCC1=NC(C2=NC(=CC=C2)C)=C(N1)C=3C=CC4=NC=NN4C3)CC=5SC=CC5

• Molecular Formula :

  C22H19N7OS

• Molecular Weight :

  429.5

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C