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ERα degrader 13

CAT: 0804-HY-172937Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172937Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ERα degrader 13 (compound MR3) is potent ERα degrader with an IC50 of 0.55 μM. ERα degrader 13 induces an obvious tumor regression in the breast cancer xenograft mouse model[1].
CAS Number
3070968-56-5
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
CCN(C1=CC=C2N=C(C(SC2=C1)=C/C3=N/CCCCCCC(NCCOC4=CC=C(C=C4)C(C5=C(SC6=C5C=CC(O)=C6)C7=CC=C(C=C7)O)=O)=O)C8=C3C=CC=C8)CC
Molecular Formula
C50H48N4O5S2
Molecular Weight
849.07
References & Citations
[1]Zhang Y, et al. Rational Design of Methylene Blue-Raloxifene Conjugates for Efficient Breast Tumor Elimination Triggered by ERα Degradation. J Med Chem. 2025 Apr 24;68 (8) :8861-8872.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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