ERα degrader 9

• UNSPSC Description:

  ERα degrader 9 is a dual targeting ligand for estrogen receptor α (ERα) and aromatase (ARO). ERα degrader 9 can be utilized for synthesis of PROTAC ERα Degrader-9 (HY-163679)[1].

• Target Antigen:

  Cytochrome P450; Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/erα-degrader-9.html

• Smiles:

  OC1=CC=C(C2=C([C@@H]3C(C[C@H]2O3)S(N(CC(F)(F)F)C4=CC=C(C=C4)O)(=O)=O)C5=CC=C(C=C5)N6C=CN=C6)C=C1

• Molecular Weight:

  583.58

• References & Citations:

  [1]Xin L, et al., Discovery of Novel ERα and Aromatase Dual-Targeting PROTAC Degraders to Overcome Endocrine-Resistant Breast Cancer. J Med Chem. 2024 Jun 13;67(11):8913-8931.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported