ERα degrader 11

ERα degrader 11

• CAS Number: 3052336-87-2
• UNSPSC Description: ERα degrader 11 (compound B16) is a selective ERα degrader that can be used as an estrogen receptor probe to investigate ER status in ER-positive breast cancer cells[1].
• Target Antigen: Estrogen Receptor/ERR
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/erα-degrader-11.html
• Smiles: CCN(C1=CC(C(F)(F)F)=CC=C1N2CC3=CC=C(O)C=C3CC2)CC4=CC=C(/C=C/C(O)=O)C=C4
• Molecular Weight: 496.52
• References & Citations: [1]Lu Y, et al. Discovery of non-antiproliferative selective estrogen receptor degraders (SERDs) based on scaffold optimization of elacestrant. Eur J Med Chem. 2024 Sep 21;279:116897.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported