ERα degrader 11

• CAS Number:

  3052336-87-2

• UNSPSC Description:

  ERα degrader 11 (compound B16) is a selective ERα degrader that can be used as an estrogen receptor probe to investigate ER status in ER-positive breast cancer cells[1].

• Target Antigen:

  Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/erα-degrader-11.html

• Smiles:

  CCN(C1=CC(C(F)(F)F)=CC=C1N2CC3=CC=C(O)C=C3CC2)CC4=CC=C(/C=C/C(O)=O)C=C4

• Molecular Weight:

  496.52

• References & Citations:

  [1]Lu Y, et al. Discovery of non-antiproliferative selective estrogen receptor degraders (SERDs) based on scaffold optimization of elacestrant. Eur J Med Chem. 2024 Sep 21;279:116897.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported