ER degrader 6

• UNSPSC Description:

  ER degrader 6 (compound 35s) is a potent Estrogen Receptor (ER)α degrader. ER degrader 6 disrupts the microtubule network by restraining tubulin polymerization. ER degrader 6 suppresses tumor growth without noticeable poisonousness[1].

• Target Antigen:

  Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/er-degrader-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(CCCCC[Se]C#N)NC1=CC=C(C2=C(C3=CC=C(O)C=C3)[C@H]4CC(S(N(CC)C5=C(F)C=CC=C5)(=O)=O)[C@@H]2O4)C=C1

• Molecular Weight:

  682.66

• References & Citations:

  [1]Deng X, et al. Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer. J Med Chem. 2023 Aug 24;66(16):11094-11117.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2922929-62-0