ERα degrader 4

• UNSPSC Description:

  ERα degrader 4 is an excellent and selective estrogen receptor α (ERα) degrader (IC50 of 0.31, 0.41 and 0.48 μM in MDA-MB-231, MCF-7 and MCF-7/ADR cells, respectively). ERα degrader 4 has potent inhibitory activity against MCF-7 cell lines. ERα degrader 4 is a potential SERDs candidate for the research of breast cancer[1].

• Target Antigen:

  Apoptosis; Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/erα-degrader-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@]12C[C@]3(CC[C@]([C@H](/C=C\C=C/C(OCCOCCOCCOC(CC45CC6CC(C5)CC(C6)C4)=O)=O)C)([C@@]3(C/C=C([C@@]1(C(C=C2C)=O)[H])/C=O)[H])[H])C

• Molecular Weight:

  690.91

• References & Citations:

  [1]Liang JJ, et al. Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment. Eur J Med Chem. 2022;229:114081.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported