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ALK5-IN-31

CAT: 0804-HY-151281Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151281Size:1 Each
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Description
ALK5-IN-31 (compound Ex-08) is a selective ALK-5 inhibitor (IC50≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-31 has the potential to inhibit growth of tumour in vivo. ALK5-IN-31 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1].
CAS Number
2785430-87-5
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk5-in-31.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=CC2=C(NC3=NC(NC4=CC=C(N5CCNCC5)C(F)=C4)=NC=C3)C=NN=C12
Molecular Formula
C23H23FN8
Molecular Weight
430.48
References & Citations
[1]Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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