Keap1-Nrf2-IN-12

• UNSPSC Description:

  Keap1-Nrf2-IN-12 is a potent Keap1-Nrf2 inhibitor with an IC50 value of 2.30 μM. Keap1-Nrf2-IN-12 shows metabolic stability in human liver microsomes[1].

• Target Antigen:

  Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/keap1-nrf2-in-12.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(N(CC(O)=O)CC1=CC=CC=C1CN(CC(O)=O)S(=O)(C2=CC=C(OC)C=C2)=O)(C3=CC=C(OC)C=C3)=O

• Molecular Weight:

  592.64

• References & Citations:

  [1]Abed DA, et al. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem. 2020 Mar 15;28(6):115343.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2250082-04-1