Keap1-Nrf2-IN-8

• UNSPSC Description:

  Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with IC50s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1[1].

• Target Antigen:

  Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/keap1-nrf2-in-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC=C(C=C1)S(=O)(N(C2=C3C=CC=CC3=C(C(OCC4=CC=C(C=C4)F)=C2)N(S(=O)(C5=CC=C(C=C5)C)=O)CC(O)=O)CC(O)=O)=O

• Molecular Weight:

  706.76

• References & Citations:

  [1]Lee S, et al. Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2022 Jul 5;237:114380.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2769963-54-2