Keap1-Nrf2-IN-6

Keap1-Nrf2-IN-6

• UNSPSC Description: Keap1-Nrf2-IN-6 (compound 64) is a potent and selective Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 41 nM, Kd of 68 nM[1].
• Target Antigen: Keap1-Nrf2
• Type: Reference compound
• Related Pathways: NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/keap1-nrf2-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N[C@H](CSCC2=C(C(OC[C@H]1NC([C@@H]3CCCN3C(C)=O)=O)=O)C=CC=C2C4=CC=C(C=C4)C(O)=O)C(N(C)C)=O
• Molecular Weight: 610.68
• References & Citations: [1]Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65(4):3473-3517.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported