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Keap1-Nrf2-IN-11

CAT: 0931-T72687-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T72687-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2796292-75-4
Target
Others, Nrf2, ROS Kinase, NO Synthase
Related Pathways
Tyrosine Kinase/Adaptors, Others, Immunology/Inflammation
Bioactivity
Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression of tumor necrosis factor-alpha (TNF-α) . By promoting Nrf2 nuclear translocation, it mitigates inflammation and is utilized in anti-inflammatory studies [1].
Smiles
CCN1CCN(CC1)CCC(=O)NC2=CC=C(C=C2)S(=O)(=O)N(CC(=O)N)C3=CC=C(C4=CC=CC=C43)N(CC(=O)N)S(=O)(=O)C5=CC=C(C=C5)OC
Molecular Formula
C36H43N7O8S2
Molecular Weight
765.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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