Keap1-Nrf2-IN-18

Keap1-Nrf2-IN-18

• UNSPSC Description: Keap1-Nrf2-IN-18 (Compound 22) is an orally active Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with good pharmacokinetics (PK) profiles and more potent in vivo activities in rats. Keap1-Nrf2-IN-18 has the strongest inhibitory activity in structure−activity relationship (SAR) study (KD = 0.0029 μM)[1].
• Target Antigen: Keap1-Nrf2
• Type: Reference compound
• Related Pathways: NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/keap1-nrf2-in-18.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC=C([C@@H](NC([C@H](C2=CC=C(CC3=NC=CC=C3OCC)C=C2)F)=O)[C@@H](C)C(O)=O)C=C1
• Molecular Weight: 464.53
• References & Citations: [1]Otake K, et al. Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors. J Med Chem. 2024 Feb 26.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported